The reference site for Rifampin

Rifampicin, also known as rifampin, is an antibiotic used to treat several types of bacterial infections.

WHAT IS Rifampin?

Rifampin or rifampicin (USAN) is a bacteriocidal antibiotic drug of the rifamycin group. It is a semisynthetic compound derived from Streptomyces mediterranei, and may be abbreviated as RIF, RMP, RD or R.

This medication is typically used to treat mycobacterium infections, including tuberculosis and leprosy, has a role in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in combination with fusidic acid, and is also used in prophylactic therapy against Neisseria meningitidis (meningococcal) infection.

Additionally, this medication is also used to treat listeria species, neisseria gonorrhoeae, haemophilus influenzae and legionella pneumophila. For these non-standard indications, sensitivity testing should be done (if possible) before starting rifampicin therapy. Rifampicin resistance develops quickly during treatment and rifampicin monotherapy should not be used to treat these infections – it should be used in combination with other antibiotics.

Furthermore, enterobacteriaceae, acinetobacter and pseudomonas species are intrinsically resistant to rifampicin. This means that rifampicin will prevent you from spreading these bacteria to other people, but will not be effective in treating any infections caused by them.

In the US, rifampicin is marketed as Rifadin® (Aventis) and Rimactane® (Novartis).

 

Brand Name(s): Rifadin; Rimactane; Rofact
CAS nº: 13292-46-1
(rif AM pin)

 

Product Info

The sections below will provide you with more specific information and guidelines related to rifampin (rifampicin) and its correct use. Please read them carefully.

FDA Information

Rifampin (rifampicin) was approved by the US FDA in 1997. A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Rifampin or rifampicin (USAN) is a bacteriocidal antibiotic drug of the rifamycin group. It is a semisynthetic compound derived from Streptomyces mediterranei, and may be abbreviated as RIF, RMP, RD or R.

This medication is typically used to treat mycobacterium infections, including tuberculosis and leprosy, has a role in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in combination with fusidic acid, and is also used in prophylactic therapy against Neisseria meningitidis (meningococcal) infection.

Additionally, this medication is also used to treat listeria species, neisseria gonorrhoeae, haemophilus influenzae and legionella pneumophila. For these non-standard indications, sensitivity testing should be done (if possible) before starting rifampicin therapy. Rifampicin resistance develops quickly during treatment and rifampicin monotherapy should not be used to treat these infections – it should be used in combination with other antibiotics.

Furthermore, enterobacteriaceae, acinetobacter and pseudomonas species are intrinsically resistant to rifampicin. This means that rifampicin will prevent you from spreading these bacteria to other people, but will not be effective in treating any infections caused by them.

Mechanism of action:

Rifampicin inhibits DNA-dependent RNA polymerase in bacterial cells by binding its beta subunit, thus preventing transcription of messenger RNA (mRNA) and subsequent translation to proteins.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Rifampin (rifampicin) comes as a capsule, suspension, or injection.

Use rifampin exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take the rifampin capsule on an empty stomach 1 hour before or 2 hours after meals. Swallow the capsule with a full glass (8 ounces) of water.

Use the rifampin for as many days as it was prescribed for you, even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated. Please note that rifampin will not treat a viral infection such as the common cold or flu.

Injectable rifampin should only be administered under the supervision of a qualified healthcare provider. Talk to your healthcare provider if you have questions regarding injectable rifampin.

What special precautions should I follow?

BEFORE TAKING RIFAMPIN:

Tell your doctor if you have ever had an allergic reaction to rifampin, have liver disease, or porphyria. You may not be able to use rifampin, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Moreover, please inform your doctor if you are also using any of the following drugs: acetaminophen (Tylenol®, others); blood thinners such as warfarin (Coumadin®); barbiturates such as phenobarbital (Luminal®, Solfoton®), amobarbital (Amytal®), secobarbital (Seconal®), and butabarbital (Butisol®); benzodiazepines such as alprazolam (Xanax®), diazepam (Valium®), lorazepam (Ativan®), and temazepam (Restoril®); beta-blockers such as atenolol (Tenormin®), propranolol (Inderal®), and metoprolol (Lopressor®); clofibrate (Atromid-S®); corticosteroids such as prednisone (Deltasone®, Orasone®, Meticorten®), prednisolone (Delta Cortef®, Prelone®, others), methylprednisolone (Medrol®), and betamethasone (Celestone®); estrogens (such as Premarin®Ogen®Estrace®Menest®Estratab®Ortho-Est®, and others); heart medicines such as digoxin (Lanoxin®), disopyramide (Norpace®), quinidine (Quinora®, Quinidex®, Cardioquin®, others), mexiletine (Mexitil®), tocainide (Tonocard®), verapamil (Calan®, Verelan®, Isoptin®), and enalapril (Vasotec®); HIV medicines such as delavirdine (Rescriptor®), saquinavir (Invirase®, Fortovase®), ritonavir (Norvir®), nelfinavir (Viracept®), and others; ketoconazole (Nizoral®), itraconazole (Sporanox®), and fluconazole (Diflucan®); methadone (Dolophine®); oral birth control pills (Triphasil®Ortho-Novum®Ortho-Cyclen®Ortho-Tri-Cyclen®Ovral®Desogen®Nordette®Levora®Levlen®Tri-Levlen®Nelova®Norinyl®Brevicon®Ovcon®Loestrin®Demulen®, and others); phenytoin (Dilantin®), ethotoin (Peganone®), and mephenytoin (Mesantoin®); sulfa medicines such as sulfamethoxazole (Bactrim®, Septra®, Gantanol®, Azo-Gantanol®), and sulfisoxazole (Gantrisin®, Azo-Gantrisin®); sulfonylureas such as glipizide (Glucotrol®), glyburide (Micronase®, Diabeta®, Glynase®), chlorpropamide (Diabinese®), tolbutamide (Orinase®), and tolazamide (Tolinase®); cyclosporine (Sandimmune®, Neoral®); theophylline (Theolair®, Theo-Dur®, Theochron®, Theo-Bid®, others).

There may be other drugs that can interact with rifampin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines including vitamins, minerals, and herbal products.

Rifampin is in the FDA pregnancy category C. This means that it is not known whether rifampin will harm an unborn baby. Do not use this medication without telling your doctor if you are pregnant.

Furthermore, rifampin passes into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Additionally, do not wear contact lenses while taking rifampin. This medicine may turn your tears, sweat, saliva, urine, feces, and contact lenses a red-orange color. This effect may permanently stain soft contact lenses.

Please note that rifampin may decrease the effectiveness of birth control pills. Talk to your doctor about using another form of birth control during treatment with rifampin.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed.

It is strongly advised never to take extra medicine to make up for a missed dose.

What side effects can this medication cause?

If you experience any of the following serious side effects, stop taking rifampin and seek medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives)
fever or chills
a sore throat
pain or swelling of the joints
excessive tiredness or weakness
a headache
nausea, vomiting, diarrhea, or loss of appetite
unusual bruising or bleeding
little or no urine
yellow skin or whites of the eyes
a rash or itching

Other, less serious side effects may be more likely to occur. Continue using rifampin and talk to your doctor if you experience:

red-orange coloration of tears, sweat, saliva, urine, or feces
mild tiredness or weakness

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Please remember to throw away any medication that is outdated or no longer needed. If you have any doubts, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services immediately on 911.

Symptoms of overdose may include:

nausea
vomiting
tiredness
stomach pain
itching
headache
weakness or fainting
fast or irregular heartbeat
jaundice (yellowing of the skin or eyes)

Product Images

PICTURES OF RIFAMPIN PRODUCTS

Below you will find images and specific information on the principal types of rifampin that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: RIFADIN®
Strength(s): 150 MG
Imprint: LOGO 801
Manufacturer: EON LABS.

Name: RIFAMPIN
Strength(s): 150 MG
Imprint: RIFMPIN 150 | VP/015
Manufacturer: VERSAPHARM INC.

Name: RIFADIN®
Strength(s): 300 MG
Imprint: RIFADIN 300
Manufacturer: SANOFI-AVENTIS

Name: RIFADIN®
Strength(s): 300 MG
Imprint: LOGO 199
Manufacturer: EON LABS.

Name: RIFAMPIN
Strength(s): 300 MG
Imprint: RIFAMPIN 300 | VP/018
Manufacturer: VERSAPHARM INC.

Name: RIFAM®
Strength(s): 300 MG
Imprint: RIFAM 300
Manufacturer: SM PHARMACEUTICALS

Name: RIFAMPIN INJECTION
Strength(s): 600 MG
Imprint: Rifampin for Injection, USP
Manufacturer: BEDFORD LABS.

Name: RIFADIN® INJECTION
Strength(s): 600 MG
Imprint: RIFADIN I.V. – Rifampin for Injection
Manufacturer: HOECHST-MARION-ROUSSEL, INC.

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